The I-35W Saint Anthony Falls Bridge crosses the Mississippi River one-half mile downstream from the Saint Anthony Falls in Minneapolis, Minnesota in the U.S., carrying north–south traffic on Interstate 35W. The ten-lane bridge replaced the I-35W Mississippi River bridge, which collapsed on August 1, 2007. It was planned and is maintained by the Minnesota Department of Transportation (MnDOT). The planning, design, and construction processes were completed more quickly than normal because Interstate 35W is a critical artery for commuters and truck freight. The bridge opened September 18, 2008, well ahead of the original goal of December 24.

Saint Anthony Falls, or the Falls of Saint Anthony, located at the northeastern edge of downtown Minneapolis, Minnesota, is the only natural major waterfall on the Mississippi River. Throughout the mid-to-late 1800s, various dams were built atop the east and west faces of the falls to support the milling industry that spurred the growth of the city of Minneapolis. In 1880, the central face of the falls was reinforced with a sloping timber apron to stop the upstream erosion of the falls. In the 1950s, the apron was rebuilt with concrete, which makes up the most visible portion of the falls today. A series of locks were constructed in the 1950s and 1960s to extend navigation to points upstream.