SUMMARY / RELATED TOPICS

Ida Lupino

Ida Lupino was an English-American actress, singer and producer. She is regarded as one of the most prominent female filmmakers working during the 1950s in the Hollywood studio system. With her independent production company, she co-wrote and co-produced several social-message films and became the first woman to direct a film noir with The Hitch-Hiker in 1953. Throughout her 48-year career, she made acting appearances in 59 films and directed eight others, working in the United States, where she became a citizen in 1948, she directed more than 100 episodes of television productions in a variety of genres including westerns, supernatural tales, situation comedies, murder mysteries, gangster stories. She was the only woman to direct episodes of the original The Twilight Zone series, as well as the only director to have starred in the show. Lupino was born in Herne Hill, London, to actress Connie O'Shea and music hall comedian Stanley Lupino, a member of the theatrical Lupino family, which included Lupino Lane, a song-and-dance man.

Her father, a top name in musical comedy in the UK and a member of a centuries-old theatrical dynasty dating back to Renaissance Italy, encouraged her to perform at an early age. He built a backyard theatre for Lupino and her sister Rita, who became an actress and dancer. Lupino toured with a traveling theater company as a child. By the age of ten, Lupino had memorized the leading female roles in each of Shakespeare's plays. After her intense childhood training for stage plays, Ida's uncle Lupino Lane assisted her in moving towards film acting by getting her work as a background actor at British International Studios, she wanted to be a writer, but in order to please her father, Lupino enrolled in the Royal Academy of Dramatic Art. She excelled in a number of "bad girl" film roles playing prostitutes. Lupino did not enjoy being an actress and felt uncomfortable with many of the early roles she was given, she felt. Lupino worked as screen actress, she first took to the stage in 1934 as the lead in The Pursuit of Happiness at the Paramount Studio Theatre.

Lupino made her first film appearance in The Love Race and the following year, aged 14, she worked under director Allan Dwan in Her First Affaire, in a role for which her mother had tested. She played leading roles in five British films in 1933 at Warner Bros.' Teddington studios and for Julius Hagen at Twickenham, including The Ghost Camera with John Mills and I Lived with You with Ivor Novello. Dubbed "the English Jean Harlow", she was discovered by Paramount in the 1933 film Money for Speed, playing a good girl/bad girl dual role. Lupino claimed the talent scouts saw her play only the sweet girl in the film and not the part of the prostitute, so she was asked to try out for the lead role in Alice in Wonderland; when she arrived in Hollywood, the Paramount producers did not know what to make of their sultry potential leading lady, but she did get a five-year contract. Lupino starred in over a dozen films in the mid-1930s, working with Columbia in a two-film deal, one of which, The Light That Failed, was a role she acquired after running into the director's office unannounced, demanding an audition.

After this performance, she began to be taken as a dramatic actress. As a result, her parts improved during the 1940s, she jokingly referred to herself as "the poor man's Bette Davis", taking the roles that Davis refused. Mark Hellinger, associate producer at Warner Bros. was impressed by Lupino's performance in The Light That Failed, hired her for the femme-fatale role in the Raoul Walsh-directed They Drive by Night, opposite stars George Raft, Ann Sheridan and Humphrey Bogart. The film did well and the critical consensus was that Lupino stole the movie in her unhinged courtroom scene. Warner Bros. offered her a contract. She worked with Walsh and Bogart again in High Sierra, where she impressed critic Bosley Crowther in her role as "adoring moll."Her performance in The Hard Way won the New York Film Critics Circle Award for Best Actress. She starred in Pillow to Post, her only comedic leading role. After the drama Deep Valley finished shooting, neither Warner Bros. nor Lupino moved to renew her contract and she left the studio in 1947.

Although in demand throughout the 1940s, she never became a major star, but was critically lauded for her tough, direct acting style. She incurred the ire of studio boss Jack Warner by objecting to her casting, refusing roles that she felt were "beneath her dignity as an actress," and making script revisions deemed unacceptable; as a result, she spent a great deal of her time at Warner Bros. suspended. In 1942, she rejected an offer to star with Ronald Reagan in Kings Row, was put on suspension at the studio. A tentative rapprochement was brokered, but her relationship with her studio remained strained. In 1947, Lupino left Warner Brothers and appeared for 20th Century Fox as a nightclub singer in the film noir Road House, performing her musical numbers in the film, she starred in On Dangerous Ground in 1951, may have taken on some of the directing tasks of the film while director Nicholas Ray was ill. While on suspension, Lupino had ample time to observe filming and editing processes, she became interested in directing.

She described how bored she was on set while "someone else seemed to be doing all the interesting work." She and her husband Collier Young formed an independent company, The Filmakers, to pro

Engineer and Logistic Staff Corps

The Engineer and Logistic Staff Corps is a part of the Royal Engineers in the British Army Reserve. It is intended to provide advisers on engineering and logistics to the British Army at a senior level; the unit was founded by William McMurdo as the Engineer and Railway Staff Corps in 1865 to ensure "the combined action among all the railways when the country is in danger" and tasked with "the preparation, during peace, of schemes for drawing troops from given distant parts and for concentrating them within given areas in the shortest possible time". The original establishment was 21 commissioned officers made up of civil engineers alongside a few railway company managers; the number of officers was expanded to 110 in 1908 before being subsequently reduced to the current strength of 60 officers. The unit was always a volunteer unit, with members retaining their civilian jobs; until its reorganisation in 1943 its members were entitled to wear a uniform similar to that of the Royal Engineers. In recent times recruitment has diversified from road and port specialists to cover all aspects of engineering.

It began to advise the Royal Corps of Transport and was renamed the Engineer and Transport Staff Corps in 1984 to reflect this. Following the creation of the Royal Logistic Corps in 1993 the unit was renamed again to the Engineer and Logistic Staff Corps; the unit is organisationally part of HQ Engineer in Chief, is constituted under the Reserve Forces Act 1996 and administered by the Ministry of Defence. Members hold their commissions as officers in the Royal Engineers and are grouped into four directorates: engineering; the establishment strength of 60 officers consists of 10 Colonels, 20 Lieutenant Colonels and 30 Majors. Membership is by invitation only and promotion follows seniority with some discretion to allow for individual officers' statuses in their profession and their level of participation in the corps. Officers who cease to be engaged in a relevant profession must offer to resign their commissions but may retain their appointment on the Commanding Officer's recommendation and with the approval of the Army Board of the Defence Council.

All officers of the corps are briefed to expect calls at any time to provide impartial and confidential advice to the British Armed Forces. Officers are invited to relevant army conferences and equipment demonstrations to keep them up to date with current capabilities; the corps is administered by a council of senior corps officers, chaired by the Commanding Officer and assisted by the Acting Adjutant, who acts as the council's secretary. The Acting Adjutant is always a retired army officer working in a relevant profession who acts as a point of contact for advice; the current officers are chief executives and senior managers of 60 different engineering and logistics organisations, which together employ 100,000 people. The corps has advised British forces in the following operations, amongst others: Gulf War Bosnian War Kosovo War Afghanistan War Iraq WarIn addition to peacetime roles in infrastructure, training and logistics. Notable members have included: John Elliot Alexander Valentine Kirby Laing Vernon Robertson Robert Elliott-Cooper John Clarke Hawkshaw Josiah Stamp, 1st Baron Stamp Ian McDonald Campbell George Humphreys Henry Cronin Charles Langbridge Morgan Allan Quartermaine Ernest Crosbie Trench Albert Stanley, 1st Baron Ashfield William McMurdo David Mowat Watson Wilfred Shepherd-Barron Jonathan Davidson William Pollitt Francis Marindin William Henry Barlow Benjamin Blyth II Cuthbert A. Brereton Mike Cottell John Crackett.

Sam Fay Maurice Fitzmaurice William Francis Harrison Hayter James Charles Inglis Ernest Lemon John Robinson McClean Alexander Ross William Grierson John Holmes Jellett Ralph Freeman Hubert Shirley-Smith Francis Wentworth-Shields Augustus Charles Newman Mike Cottell Engineer and Logistic Staff Corps website Back to the future - 2016 Chartered Institute of Logistics and Transport article on the corps

Branimir Ivan Sikic

Branimir Ivan Sikic is an American medical doctor and scientist at Stanford University School of Medicine. He is an oncologist and cancer pharmacologist, has served as a faculty member at Stanford University since 1979, his research spans basic and clinical research and investigates the mechanisms of drug resistance and the development of new anticancer therapies. Sikic was born in Graz, Austria, on October 18, 1947, his parents were his father a mathematician and his mother a linguist. The family emigrated to Adelaide, Australia in 1949, to Cincinnati, Ohio in 1956. Sikic graduated from St. Xavier High School as president of his class in 1964 at age 16, attended Georgetown University in Washington, D. C. where he obtained a B. S. degree in Biology in 1968. Sikic attended the University of Chicago Pritzker School of Medicine, graduating with an M. D. in 1972. He returned to Georgetown University Hospital in Washington, D. C. for an internship and residency in internal medicine. From 1975-8 he was a postdoctoral laboratory research fellow at the National Institutes of Health, working on the regulation of drug metabolism and the pharmacology and pulmonary toxicology of the anticancer drug bleomycin.

He returned to Georgetown in 1978-9 to complete a clinical fellowship in medical oncology, prior to joining the faculty at Stanford University. In 1992 Sikic began directing the General Clinical Research Center and the Center for Clinical and Translational Research in 2008, he is the founder and director of the Central European Oncology Congress held in Opatija, Croatia since 1998. In 2010 he was awarded the Katarina Zrinska Medal for Science and Medicine by the President of Croatia. Sikic has made significant contributions to understanding the biology and clinical significance of multidrug resistance the P-glycoprotein multidrug transporter and regulation of the ABCB1 gene, he discovered that deletion of aa335 changes the drug-binding spectrum and is integral to the pharmacophore of P-gp. He defined specific sites of transactivation of ABCB1, mechanisms of amplification of the gene; the laboratory work on drug resistance mechanisms led to a series of clinical Phase I-III trials that defined this field.

Early on, Sikic's group found that P-gp inhibition resulted in significant pharmacokinetic alterations of several anticancer drugs, with the potential for markedly increased toxicities unless doses were adjusted. These findings, the co-existence of other resistance mechanisms in human cancers, redefined the field and demonstrated the limited clinical utility of MDR modulation; the Sikic group utilized gene expression profiling and systems biology to yield insight into cancer taxonomy and prognostic and predictive signatures for cancer therapies. With their colleagues Olivier Gevaert and Sylvia Plevritis, they have identified driver genes for ovarian cancers. SPECTRUM: Clinical & Translational Research Unit Cancer Molecular Therapeutics Research Association