Il furioso all'isola di San Domingo (The Madman on the Island of San Domingo) is a "romantic melodramma" in two acts by the composer Gaetano Donizetti. Jacopo Ferretti, who since 1821 had written five libretti for Donizetti and two for Rossini, had proposed the unusual subject and he was contracted to write the Italian libretto based on a five-act play of the same title by an unknown author in 1820, which "had been given in the same theatre [...] and which Donizetti had immediately loved". However, as has been noted by Charles Osborne, the "ultimate derivation of both play and libretto is an episode in part 1 of Don Quixote by Miguel de Cervantes's published in 1605" which is the story of Cardenio and Lucinda.

Domenico Gaetano Maria Donizetti was an Italian composer, best known for his almost 70 operas. Along with Gioachino Rossini and Vincenzo Bellini, he was a leading composer of the bel canto opera style during the first half of the nineteenth century and a probable influence on other composers such as Giuseppe Verdi. Donizetti was born in Bergamo in Lombardy. At an early age he was taken up by Simon Mayr who enrolled him with a full scholarship in a school which he had set up. There he received detailed musical training. Mayr was instrumental in obtaining a place for Donizetti at the Bologna Academy, where, at the age of 19, he wrote his first one-act opera, the comedy Il Pigmalione, which may never have been performed during his lifetime.