The illegal drug trade in Colombia has, since the 1970s, centered successively on four major drug trafficking cartels: Medellín, Cali, Norte del Valle, and North Coast, as well as several bandas criminales, or BACRIMs. The trade eventually created a new social class and influenced several aspects of Colombian culture, economics, and politics.

A drug cartel is a criminal organization composed of independent drug lords who collude with each other in order to improve their profits and dominate the illegal drug trade. Drug cartels form with the purpose of controlling the supply of the illegal drug trade and maintaining prices at a high level. The formations of drug cartels are common in Latin American countries. Rivalries between multiple drug cartels cause them to wage turf wars against each other.