Illinois Route 41 is a north–south route in rural west-central Illinois. It runs from U.S. Route 136 near Macomb north to U.S. Route 34 and Illinois Route 164 in Galesburg, a distance of 37.53 miles (60.40 km). Illinois 41 is maintained by the Illinois Department of Transportation.

Galesburg is a city in Knox County, Illinois, United States. The city is 45 miles (72 km) northwest of Peoria. At the 2010 census, its population was 32,195. It is the county seat of Knox County and the principal city of the Galesburg Micropolitan Statistical Area, which includes all of Knox and Warren counties.