Illinois Route 49 is a 140.86-mile-long (226.69 km) north–south state highway in east-central Illinois. It runs from Willow Hill at IL 33 north to the beginning of the U.S. Route 45/52 concurrency near Ashkum.

Illinois Route 33 (IL 33) is a multidirectional highway in southeastern Illinois, with its western terminus at Illinois Route 128 on the Fayette–Effingham county line near Beecher City and its southern terminus at U.S. Route 50 east of Lawrenceville. It also overlaps Illinois Route 32 from Shumway to Effingham. The east–west portion of the highway is roughly 75 miles (121 km) long, and the north–south portion is about 22 miles (35 km) in length. This makes for a total distance of 97.17 miles (156.38 km).