Interplanetary spaceflight or interplanetary travel is the crewed or uncrewed travel between stars and planets, usually within a single planetary system. In practice, spaceflights of this type are confined to travel between the planets of the Solar System. Uncrewed space probes have flown to all the observed planets in the Solar System as well as to dwarf planets Pluto and Ceres, and several asteroids. Orbiters and landers return more information than fly-by missions. Crewed flights have landed on the Moon and have been planned, from time to time, for Mars, Venus and Mercury. While many scientists appreciate the knowledge value that uncrewed flights provide, the value of crewed missions is more controversial. Science fiction writers propose a number of benefits, including the mining of asteroids, access to solar power, and room for colonization in the event of an Earth catastrophe.

Spaceflight is an application of astronautics to fly objects, usually spacecraft, into or through outer space, either with or without humans on board. Most spaceflight is uncrewed and conducted mainly with spacecraft such as satellites in orbit around Earth, but also includes space probes for flights beyond Earth orbit. Such spaceflight operate either by telerobotic or autonomous control. The more complex human spaceflight has been pursued soon after the first orbital satellites and has reached the Moon and permanent human presence in space around Earth, particularly with the use of space stations. Human spaceflight programs include the Soyuz, Shenzhou, the past Apollo Moon landing and the Space Shuttle programs. Other current spaceflight are conducted to the International Space Station and to China's Tiangong Space Station.