Interstate 10 (I-10) in the US state of New Mexico is a 164.264-mile (264.357 km) long route of the United States Interstate Highway System. I-10 traverses southern New Mexico through Hidalgo, Grant, Luna, and Doña Ana counties. The interstate travels west–east from the Arizona state line to the interchange with I-25 in Las Cruces, and then travels north–south to the Texas state line. US Route 80 in New Mexico (US 80) was replaced by I-10.

Luna County (Spanish: Condado de Luna) is a county located in the U.S. state of New Mexico. As of the 2020 census, the population was 25,427. Its county seat is Deming. This county abuts the Mexican border. Luna County comprises the Deming, NM Micropolitan Statistical Area.