Interstate 25 (I-25) in the US state of New Mexico follows the north–south corridor through Albuquerque and Santa Fe. It replaced U.S. Route 85 (US 85), which is no longer signed, but still exists in route logs sharing most of the I-25 alignment. I-25 starts in New Mexico at an interchange with I-10 in Las Cruces and extends roughly 460 miles (740 km) before reaching Colorado. I-25 passes through principally rural land through central New Mexico and passes through or near the cities of Las Cruces, Truth or Consequences, Socorro, Belen, Albuquerque, Santa Fe, Las Vegas, and Raton.

Interstate 10 (I-10) in the US state of New Mexico is a 164.264-mile (264.357 km) long route of the United States Interstate Highway System. I-10 traverses southern New Mexico through Hidalgo, Grant, Luna, and Doña Ana counties. The interstate travels west–east from the Arizona state line to the interchange with I-25 in Las Cruces, and then travels north–south to the Texas state line. US Route 80 in New Mexico (US 80) was replaced by I-10.