In the US state of Colorado, Interstate 25 (I-25) follows the north–south corridor through Colorado Springs and Denver. The highway enters the state from the north near Carr and exits the state near Starkville. The highway also runs through the cities of Fort Collins, Broomfield, Loveland, and Pueblo. The route is concurrent with U.S. Route 87 (US 87), which is unsigned, through the entire length of the state. I-25 replaced US 87 and most of US 85 for through traffic.

Colorado Springs is a city in and the county seat of El Paso County, Colorado, United States. It is the most populous city in El Paso County, with a population of 478,961 at the 2020 census, a 15.02% increase since 2010. Colorado Springs is the second-most populous city and the most extensive city in the state of Colorado, and the 39th-most-populous city in the United States. It is the principal city of the Colorado Springs metropolitan area and the second-most prominent city of the Front Range Urban Corridor. It is located in east-central Colorado on Fountain Creek, 70 miles (113 km) south of Denver.