Interstate 220 (I-220) in Mississippi is a loop around Jackson that provides an Interstate connection for I-55 and I-20. The northern terminus for the route is in the suburb of Ridgeland, at I-55 exit 104. The highway was Mississippi's first auxiliary Interstate, complete by 1981.

U.S. Route 49 is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route 62/Highway 1/Highway 139 (US 62/AR 1/AR 139). Its southern terminus is in Gulfport, Mississippi, at an intersection with U.S. Route 90. US 49 is approximately 516 miles (830 km) in length.