U.S. Route 49 is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route 62/Highway 1/Highway 139 (US 62/AR 1/AR 139). Its southern terminus is in Gulfport, Mississippi, at an intersection with U.S. Route 90. US 49 is approximately 516 miles (830 km) in length.
Southern terminus of US 49 at US 90 in Gulfport
US 49W passing through the Mississippi Delta north of Yazoo City
The legendary "Crossroads" at Clarksdale, the inspiration for the song "Cross Road Blues"
Split of US 49 in Tutwiler
United States Numbered Highway System
The United States Numbered Highway System is an integrated network of roads and highways numbered within a nationwide grid in the contiguous United States. As the designation and numbering of these highways were coordinated among the states, they are sometimes called Federal Highways, but the roadways were built and have always been maintained by state or local governments since their initial designation in 1926.
The "final" U.S. Highway plan as approved November 11, 1926
This sign, photographed in 1941 on US 99 between Seattle, Washington, and Portland, Oregon, illustrates one rationale for a federal highway system: national defense.