Interstate 27 (I-27) is an Interstate Highway, entirely in the US state of Texas, running north from Lubbock to I-40 in Amarillo. These two cities are the only control cities on I-27; other cities and towns served by I-27 include New Deal, Abernathy, Hale Center, Plainview, Kress, Tulia, Happy, and Canyon. In Amarillo, I-27 is commonly known as the Canyon Expressway, although it is also called Canyon Drive on its access roads. I-27 was officially designated the Marshall Formby Memorial Highway after former attorney and State Senator Marshall Formby in 2005. The entire length of I-27 replaced US Highway 87 (US 87) for through traffic. An extension of I-27 north to Raton, New Mexico, and south to Laredo, Texas, was approved in 2022.

Lubbock is a city in the U.S. state of Texas and the seat of Lubbock County. With a population of 263,930 in 2022, the city is the 10th-most populous city in Texas and the 85th-most populous in the United States. The city is in the northwestern part of the state, an area known historically and geographically as the Llano Estacado, and ecologically is part of the southern end of the High Plains, lying at the economic center of the Lubbock metropolitan area, which had an estimated population of 360,104 in 2023.