Interstate 275 (I-275) is an Interstate Highway in Tennessee that serves Knoxville by connecting the downtown with I-75/I-640/US Route 25W (US 25W). Measuring 2.98 miles (4.80 km) in length, it runs from a northern terminus at the junction with I-75/I-640/US 25W to a southern terminus at I-40. I-275 was formerly a section of I-75, which was rerouted onto I-640 in 1980 after a section of that route was completed.

Knoxville is a city in and the county seat of Knox County, Tennessee, United States. As of the 2020 United States census, Knoxville's population was 190,740, making it the largest city in the East Tennessee Grand Division and the state's third-most-populous city after Nashville and Memphis. It is the principal city of the Knoxville metropolitan area, which had a population of 879,773 in 2020.