Interstate 37 (I-37) is a 143-mile (230 km) Interstate Highway located within the southern portion of the US state of Texas. The highway was first designated in 1959 as a route between Corpus Christi and San Antonio. Construction in the urban areas of Corpus Christi and San Antonio began in the 1960s, and the segments of the Interstate Highway in rural areas were completed by the 1980s. Prior to I-37, the route between Corpus Christi and San Antonio was served by a combination of State Highway 9 (SH 9) from Corpus Christi to Three Rivers and US Highway 281 (US 281) from Three Rivers to San Antonio. As a result of the construction of I-37, SH 9 was removed from the State Highway System.

Corpus Christi is a coastal city in the South Texas region of the U.S. state of Texas and the county seat and largest city of Nueces County with portions extending into Aransas, Kleberg, and San Patricio counties. It is 130 miles (210 km) southeast of San Antonio and 208 miles (335 km) southwest of Houston. Its political boundaries encompass Nueces Bay and Corpus Christi Bay. Its zoned boundaries include small land parcels or water inlets of three neighboring counties.