Interstate 380 (I-380) is an auxiliary Interstate Highway in Northeastern Pennsylvania that connects I-80 with I-81 and I-84. The southern terminus is in Tunkhannock Township at the junction with I-80; the northern terminus of I-380 is at I-81 and U.S. Route 6 (US 6) in Dunmore. The entire length of the highway is 28.45 miles (45.79 km).

Interstate 80 (I-80) in the US state of Pennsylvania runs for 311.12 miles (500.70 km) across the central part of the state. It is designated as the Keystone Shortway and officially as the Z.H. Confair Memorial Highway. This route was built mainly along a completely new alignment, not paralleling any earlier US Routes, as a shortcut to the tolled Pennsylvania Turnpike to the south and New York State Thruway to the north. It does not serve any major cities in Pennsylvania and is mainly a cross-state route on the Ohio–New York City corridor. Most of I-80's path across the state goes through hilly and mountainous terrain, while the route passes through relatively flat areas toward the western part of the state.