Interstate 395 (I-395) is a 4.99-mile-long (8.03 km) auxiliary Interstate Highway in the U.S. state of Maine. The western terminus of the route is at a cloverleaf interchange with I-95 near downtown Bangor, where I-395 continues west as US Route 2 (US 2) and State Route 100 (SR 100). The eastern terminus is at US 1A in Brewer.

Interstate 95 (I-95) is a part of the Interstate Highway System that runs north–south from Miami, Florida to Houlton, Maine. The highway enters Maine from the New Hampshire state line in Kittery and runs for 303 miles (488 km) to the Canada–United States border at Houlton. It is the only primary Interstate Highway in Maine. In 2004, the highway's route between Portland and Gardiner was changed so that it encompasses the entire Maine Turnpike, a toll road running from Kittery to Augusta. As an Interstate Highway, all of I-95 in Maine is included in the National Highway System, a network of roads important to the country's economy, defense, and mobility.