Interstate 40 (I-40) is part of the Interstate Highway System that runs 2,556.61 miles (4,114.46 km) from Barstow, California, to Wilmington, North Carolina. The highway crosses Tennessee from west to east, from the Mississippi River at the Arkansas border to the Blue Ridge Mountains at the North Carolina border. At 455.28 miles (732.70 km), the Tennessee segment of I-40 is the longest of the eight states through which it passes and the state's longest Interstate Highway.

West Tennessee is one of the three Grand Divisions of Tennessee that roughly comprises the western quarter of the state. The region includes 21 counties between the Tennessee and Mississippi rivers, delineated by state law. Its geography consists primarily of flat lands with rich soil and vast floodplain areas of the Mississippi River. Of the three regions, West Tennessee is the most sharply defined geographically, and is the lowest-lying. It is both the least populous and smallest, in land area, of the three Grand Divisions. Its largest city is Memphis, the state's second most populous city.