Interstate 43 (I-43) is a 191.55-mile-long (308.27 km) Interstate Highway located entirely within the US state of Wisconsin, connecting I-39/I-90 in Beloit with Milwaukee and I-41, U.S. Highway 41 (US 41) and US 141 in Green Bay. State Trunk Highway 32 (WIS 32) runs concurrently with I-43 in two sections and I-94, I-894, US 10, US 41, US 45, and WIS 57 overlap I-43 once each. There are no auxiliary or business routes connected to I-43, though an alternate route to direct traffic during road closures is signed along local and state highways from Milwaukee County north into Brown County.

Interstate 94 (I-94) runs east–west through the western, central, and southeastern portions of the US state of Wisconsin. A total of 348.23 miles (560.42 km) of I-94 lie in the state.