Interstate 44 (I-44) is an Interstate Highway that runs diagonally through the U.S. state of Oklahoma, spanning from the Texas state line near Wichita Falls, Texas, to the Missouri border near Joplin, Missouri. It connects three of Oklahoma's largest cities: Oklahoma City, Tulsa, and Lawton. Most of I-44 in Oklahoma is a toll road. In southwestern Oklahoma, I-44 is the H. E. Bailey Turnpike and follows a diagonally northwest–southeast direction. From Oklahoma City to Tulsa, I-44 follows the Turner Turnpike. As I-44 leaves Tulsa, it becomes the Will Rogers Turnpike to the Missouri border. In the Lawton, Oklahoma City, and Tulsa metropolitan areas, I-44 is toll-free. In Oklahoma City, I-44 is also known as the Will Rogers Expressway.

Lawton is a city in and the county seat of Comanche County, in the U.S. state of Oklahoma. Located in southwestern Oklahoma, approximately 87 mi (140 km) southwest of Oklahoma City, it is the principal city of the Lawton, Oklahoma, metropolitan statistical area. According to the 2020 census, Lawton's population was 90,381, making it the sixth-largest city in the state, and the largest in Western Oklahoma.