Interstate 480 (I-480) is a 41.77-mile-long (67.22 km) auxiliary Interstate Highway of I-80 in the US state of Ohio that passes through much of the Greater Cleveland area, including the southern parts of the city of Cleveland. I-480 is one of 13 auxiliary Interstate Highways in the state. The western terminus of I-480 is an interchange with I-80 and the Ohio Turnpike in North Ridgeville. Starting east through suburban Lorain County, I-480 enters Cuyahoga County, then approaches Cleveland Hopkins International Airport, which serves as the primary airport for Northeast Ohio. After traversing Brooklyn and crossing the Cuyahoga River on the Valley View Bridge, the highway continues east toward the communities of Bedford and Twinsburg toward its eastern terminus at I-80 and the Ohio Turnpike in Streetsboro. On its route, I-480 crosses I-71 and I-77 and is concurrent with I-271 for approximately four miles (6.4 km). In 1998, the governor of Ohio, George Voinovich, gave I-480 the additional name of the "Senator John Glenn Highway", in honor of the former NASA astronaut and US senator from Ohio for 24 years.

Interstate 271 (I-271) is an auxiliary Interstate Highway in the suburbs of Cleveland and Akron in the US state of Ohio. The highway is officially designated the Outerbelt East Freeway but is rarely referred to by that name by locals, instead simply referring to it as "271".