Interstate 490 (I-490) is an auxiliary Interstate Highway that serves the city of Rochester, New York, in the United States. It acts as a northerly alternate route to the New York State Thruway (I-90), leaving it at exit 47 in the town of Le Roy and rejoining the highway at exit 45 in the town of Victor 37.4 miles (60.2 km) to the east. I-490 connects with I-390 and New York State Route 390 (NY 390) on the western side of Rochester and I-590 and NY 590 on the east side of the city at an interchange known as the Can of Worms. The highway comprises the southernmost portion of the Inner Loop, a beltway around the interior of Rochester. Outside the city, I-490 serves several suburban villages, such as Churchville and Pittsford.

The New York State Thruway is a system of controlled-access toll roads spanning 569.83 miles (917.05 km) within the U.S. state of New York. It is operated by the New York State Thruway Authority (NYSTA), a New York State public-benefit corporation. The 496.00-mile (798.23 km) mainline is a freeway that extends from the New York City line at Yonkers to the Pennsylvania state line at Ripley by way of I-87 and I-90 through Albany, Syracuse, and Buffalo. According to the International Bridge, Tunnel and Turnpike Association, the Thruway is the fifth-busiest toll road in the United States. The toll road is also a major route for long distance travelers linking the cities of Toronto and Buffalo with Boston and New York City.