Interstate 595 (I-595), also known as the Port Everglades Expressway and unsigned Florida State Road 862, is a 12.86-mile (20.70 km) auxiliary Interstate Highway that connects I-75 and Alligator Alley in the west with Florida's Turnpike, I-95, Fort Lauderdale–Hollywood International Airport, U.S. Highway 1, and SR A1A before terminating at Port Everglades in the east. The Interstate route was conceived in 1969 and planned as an Interstate starting in 1974. Construction began in 1984, with the expressway opening in stages in the late 1980s, with completion in 1991. The reversible tolled express lanes opened in 2014.

Interstate 75 (I-75) is a part of the Interstate Highway System that runs from the Hialeah–Miami Lakes border, a few miles northwest of Miami, to Sault Ste. Marie in the Upper Peninsula of Michigan. I-75 begins its national northward journey near Miami, running along the western parts of the Miami metropolitan area before traveling westward across Alligator Alley, resuming its northward direction in Naples, running along Florida's Gulf Coast, and passing the cities of Fort Myers, Punta Gorda, Venice, and Sarasota. The freeway passes through the Tampa Bay area before turning inward toward Ocala, Gainesville, and Lake City before leaving the state and entering Georgia. I-75 runs for 471 miles (758 km) in Florida, making it the longest Interstate in the state and also the longest in any state east of the Mississippi River. The Interstate's speed limit is 70 mph (110 km/h) for its entire length in Florida.