Interstate 74 (I-74) is the central freeway through the Iowa Quad Cities. It roughly divides Davenport to the west and Bettendorf to the east. The Interstate Highway begins at an interchange with I-80 at the northeastern edge of Davenport and continues into Illinois at the Mississippi River by crossing the I-74 Bridge. The freeway was built in stages during the late 1960s and early 1970s.

Interstate 80 (I-80) is a transcontinental Interstate Highway in the United States, stretching from San Francisco, California, to Teaneck, New Jersey. In Iowa, the highway travels west to east through the center of the state. It enters the state at the Missouri River in Council Bluffs and heads east through the southern Iowa drift plain. In the Des Moines metropolitan area, I-80 meets up with I-35 and the two routes bypass Des Moines together. On the northern side of Des Moines, the Interstates split and I-80 continues east. In eastern Iowa, it provides access to the University of Iowa in Iowa City. Northwest of the Quad Cities in Walcott is Iowa 80, the world's largest truck stop. I-80 passes along the northern edge of Davenport and Bettendorf and leaves Iowa via the Fred Schwengel Memorial Bridge over the Mississippi River into Illinois.