Interstate 89 (I-89) is an Interstate Highway in the New England region of the United States traveling from Bow, New Hampshire, to the Canada–United States border between Highgate Springs, Vermont, and Saint-Armand, Quebec. As with all odd-numbered primary Interstates, I-89 is signed as a north–south highway. However, it follows a primarily northwest-to-southeast path. The route forms a major part of the main connection between the cities of Montreal and Boston. In Quebec, the route continues as Route 133. The eventual completion of Autoroute 35 will lead to a nonstop limited-access highway route between Boston and Montreal, following I-93 south from I-89's terminus. The largest cities directly served by I-89 are Concord, the state capital of New Hampshire; Montpelier, the state capital of Vermont; and Burlington, Vermont. I-89 is one of three main Interstate highways whose route is located entirely within New England, along with I-91 and I-93.

U.S. Route 2 or U.S. Highway 2 (US 2) is an east–west United States Numbered Highway spanning 2,571 miles (4,138 km) across the northern continental United States. US 2 consists of two segments connected by various roadways in southern Canada. Unlike some routes, which are disconnected into segments because of encroaching Interstate Highways, the two portions of US 2 were designed to be separate in the original 1926 highway plan.