Interstate 96 (I-96) is an east–west Interstate Highway that runs for approximately 192 miles (309 km) entirely within the Lower Peninsula of the US state of Michigan. The western terminus is at an interchange with US Highway 31 (US 31) and Business US 31 on the eastern boundary of Norton Shores southeast of Muskegon, and the eastern terminus is at I-75 near the Ambassador Bridge in Detroit. From Grand Rapids through Lansing to Detroit, the freeway parallels Grand River Avenue, never straying more than a few miles from the decommissioned US 16. The Wayne County section of I-96 is named the Jeffries Freeway from its eastern terminus to the junction with I-275 and M-14. Though maps still refer to the freeway as the Jeffries, the portion within the city of Detroit was renamed by the state legislature as the Rosa Parks Memorial Highway in December 2005 in honor of the late civil rights pioneer. There are four auxiliary Interstates as well as two current and four former business routes associated with I-96.

The Lower Peninsula of Michigan – also known as Lower Michigan – is the larger, southern and less elevated of the two major landmasses that make up the U.S. state of Michigan; the other being the Upper Peninsula, which is separated by the Straits of Mackinac. It is surrounded by water on all sides except its southern border, which it shares with Indiana and Ohio. Although the Upper Peninsula is commonly referred to as "the U.P.", it is uncommon for the Lower Peninsula to be called "the L.P."