Iowa Highway 141 (Iowa 141) is an east–west highway in the western and central portions of the state. It is the most direct link between Sioux City and Des Moines. It also serves as an expressway link between Des Moines and the outlying communities of Perry, Granger, and Grimes. Iowa 141 begins near Sloan at an interchange with Interstate 29 (I-29) at ends at another interchange with I-35 /I-80 on the edge of the Des Moines suburbs of Urbandale and Grimes.

In the US state of Iowa, Interstate 29 (I-29) is a north–south Interstate Highway which closely parallels the Missouri River. I-29 enters Iowa from Missouri near Hamburg and heads to the north-northwest through the Omaha–Council Bluffs and the Sioux City areas. It exits the state by crossing the Big Sioux River into South Dakota. For its entire distance through the state, it runs on the flat land between the Missouri River and the Loess Hills.