Ironton is a city in and the county seat of Lawrence County, Ohio, United States.The population was 10,571 at the 2020 census. Located in southernmost Ohio along the Ohio River, it is 20 miles (32 km) northwest of Huntington, West Virginia, within the Huntington–Ashland metropolitan area. The city's name is a contraction of "iron town", stemming from its long ties to the iron industry. It also had one of the first professional football teams, the Ironton Tanks.

U.S. Route 52 (US 52) is a major United States highway in the central United States that extends from the northern to southeastern region of the United States. Contrary to most other even-numbered U.S. Highways, US 52 primarily follows a northwest–southeast route, and is signed north–south or east–west depending on the local orientation of the route. The highway's northwestern terminus is in Portal, North Dakota at the Canada–United States border, where it continues as Saskatchewan Highway 39. Its southeastern terminus is in Charleston, South Carolina, at Number 2 Meeting Street and White Point Garden along the Charleston Harbor.