Izushi Jinja (出石神社) is a Shinto shrine in the Izushi neighborhood of the city of Toyooka in Hyōgo Prefecture, Japan. It is the ichinomiya of former Tajima Province. The main festival of the shrine is held annually on October 20.

Ichinomiya is a Japanese historical term referring to the Shinto shrines with the highest rank in a province. Shrines of lower rank were designated ninomiya , sannomiya , shinomiya , and so forth.