Jizzakh is a city and the center of Jizzakh Region in Uzbekistan, located in the northeast of Samarkand. Jizzakh is a district-level city. The population of Jizzakh is 179,200.

Jizzakh Region is one of the regions of Uzbekistan. It is located in the center/east of the country. It borders Tajikistan to the south and south-east, Samarqand Region to the west, Navoiy Region to the north-west, Kazakhstan to the north, and Sirdaryo Region to the east. It covers an area of 21,210 km2. The population is 1,443,408 with 53% living in rural areas.