The Johannesburg Central Business District, commonly called Johannesburg CBD, is one of the main business centres of Johannesburg, South Africa. It is the densest collection of skyscrapers in Africa, however, due to white flight and urban blight, many of the buildings are unoccupied as tenants have left for more secure locations in the Northern Suburbs, in particular Sandton and Rosebank. There are significant movements to revive the area.

Johannesburg is the most populous city in South Africa with 4,803,262 people, and is classified as a megacity; it is one of the 100 largest urban areas in the world. It is the provincial capital and largest city of Gauteng, which is the wealthiest province in South Africa. Johannesburg is the seat of the Constitutional Court, the highest court in South Africa. Most of the major South African companies and banks have their head offices in Johannesburg. The city is located within the mineral-rich Witwatersrand hills, the epicentre of the international-scale mineral, gold and (specifically) diamond trade.