John Drew Barrymore was an American film actor and member of the Barrymore family of actors, which included his father, John Barrymore, and his father's siblings, Lionel and Ethel. He was the father of four children, including actor John Blyth Barrymore and actress Drew Barrymore. Diana Barrymore was his half-sister from his father's second marriage.

The Barrymore family, and the related Drew family, form a British-American acting dynasty which traces its acting roots to the mid-19th century London stage. After migrating to the United States, members of the family appeared in motion pictures.