John Hamilton, Scottish prelate and politician, was an illegitimate son of The 1st Earl of Arran.

Gerolamo Cardano was an Italian polymath whose interests and proficiencies ranged through those of mathematician, physician, biologist, physicist, chemist, astrologer, astronomer, philosopher, writer, and gambler. He became one of the most influential mathematicians of the Renaissance and one of the key figures in the foundation of probability; he introduced the binomial coefficients and the binomial theorem in the Western world. He wrote more than 200 works on science.