John II, called the Perfect Prince, was King of Portugal from 1481 until his death in 1495, and also for a brief time in 1477. He is known for re-establishing the power of the Portuguese monarchy, reinvigorating the Portuguese economy, and renewing his country's exploration of Africa and Asia.

Isabella I, also called Isabella the Catholic, was Queen of Castile and León from 1474 until her death in 1504. She was also Queen of Aragon from 1479 until her death as the wife of King Ferdinand II. Reigning together over a dynastically unified Spain, Isabella and Ferdinand are known as the Catholic Monarchs.