Sir John Edward Sulston was a British biologist and academic who won the Nobel Prize in Physiology or Medicine for his work on the cell lineage and genome of the worm Caenorhabditis elegans in 2002 with his colleagues Sydney Brenner and Robert Horvitz. He was a leader in human genome research and Chair of the Institute for Science and Innovation at the University of Manchester. Sulston was in favour of science in the public interest, such as free public access of scientific information and against the patenting of genes and the privatisation of genetic technologies. Sulston was born in Fulmer, England to Arthur Edward Aubrey Sulston and Josephine Muriel Frearson, née Blocksidge, his father was an Anglican priest and administrator of the Society for the Propagation of the Gospel. His mother quit her job as an English teacher at Watford Grammar School, to care for him and his sister Madeleine. and home-tutored them until he was five. At age five he entered the local preparatory school, York House School, where he soon developed an aversion to games.
He developed an early interest in science, having fun with dissecting animals and sectioning plants to observe their structure and function. Sulston won a scholarship to Merchant Taylors' School, Northwood and to Pembroke College, Cambridge graduating in 1963 with a Bachelor of Arts degree in Natural Sciences, he joined the Department of Chemistry, University of Cambridge, after being interviewed by Alexander Todd and was awarded his PhD in 1966 for research in nucleotide chemistry. Between 1966 and 1969 he worked as a postdoctoral researcher at the Salk Institute for Biological Studies in La Jolla, California, his academic advisor Colin Reese had arranged for him to work with Leslie Orgel, who would turn his scientific career onto a different pathway. Orgel introduced him to Francis Sydney Brenner, who worked in Cambridge, he became inclined to biological research. Although Orgel wanted Sulston to remain with him, Sydney Brenner persuaded Sulston to return to Cambridge to work on the neurobiology of Caenorhabditis elegans at the Medical Research Council Laboratory of Molecular Biology.
Sulston soon produced the complete map of the worm's neurons. He continued work on its DNA and subsequently the whole genome sequencing. In 1998, the whole genome sequence was published in collaboration with the Genome Institute at Washington University in St. Louis, so that C. elegans became the first animal to have its complete genome sequenced. Sulston played a central role in human genome sequencing projects, he had argued for the sequencing of C. elegans to show that large-scale genome sequencing projects were feasible. As sequencing of the worm genome proceeded, the Human Genome Project began. At this point he was made director of the newly established Sanger Centre, located in Cambridgeshire, England. In 2000, after the'working draft' of the human genome sequence was completed, Sulston retired from directing the Sanger Centre. With Georgina Ferry, he narrated his research career leading to the human genome sequence in The Common Thread: A Story of Science, Politics and the Human Genome.
Sulston was elected a Fellow of the Royal Society in 1986. His certificate of election reads: John Sulston is distinguished for his work on the molecular and developmental genetics of Caenorhabditis elegans, his initial research was in the field of chemical synthesis of oligonucleotides. Sulston began his work on C. elegans in 1974 characterising its DNA. Since he has carried out a wide range of genetical and developmental studies on the nematode but his major research has been on the developmental lineage and mutations that affect it. In a series of studies, culminating in a paper published in 1983, Sulston has analysed and described the total cell lineage of the nematode making it the first organism for which the origin of every cell is known; this work is the basis for the study of mutations affecting lineages and is the foundation on which detailed studies of development in this organism will be based. Sulston has now turned his attention to an analysis of the genome of C. elegans and was constructing a total physical map using a novel method of analysing cloned DNA fragments.
He was elected an EMBO Member in 1989 and awarded the George W. Beadle Award in 2000. In 2001 Sulston gave the Royal Institution Christmas Lectures on The Secrets of Life. In 2002, he won the Robert Burns Humanitarian Award, he shared the Nobel Prize in Physiology or Medicine with Sydney Brenner and Robert Horvitz, both of whom he had collaborated with at the MRC Laboratory of Molecular Biology, for their discoveries concerning'genetic regulation of organ development and programmed cell death'. One of Sulston's most important contributions during his research years at the LMB was to elucidate the precise order in which cells in C. elegans divide. In fact, he and his team succeeded in tracing the nematode's entire embryonic cell lineage. In 2006, he was awarded the George Dawson Prize in Genetics by Trinity College Dublin. In 2013, Sulston was awarded the Royal Society of New Zealand's Rutherford Memorial Lecture, which he gave on the subject of population pressure, he was appointed a Member of the Order of the Companions of Honour in the 2017 Birthday Honours for services to science and society.
On 23 October 2017 he was awarded the Cambridge Chemistry Alumni Medal. Sulston was a leading campaigner against the patenting of human genetic information. John Sulston met a research assistant in Cambridge, they got married in 1966. Together they had two children, their first child, was born in La Jo
Vincent M. Ward known as Vincent Ward, is an American actor, he is best known for his roles on The Walking Dead. Vincent M. Ward is a Ohio native. Ward graduated from Trotwood-Madison High School in Ohio. Ward has had a host of small roles in film and television such as a bodyguard on Everybody Hates Chris, Hollis on True Blood, a bodyguard in Hot in Cleveland, Darren, a mailman in Wilfred, his most notable television roles are Bo in The Starter Wife, Oscar on The Walking Dead. Ward's film work includes Ocean's Eleven, Live-Evil, 2016. Ward played the role of Kenzo in the play "Nylons" by Brandi Burks in Los Angeles in 2011. In 2015 Ward performed in The Conversation at the AMCE Hollywood. In 2012 Ward released. Official website Vincent M. Ward on IMDb
Colebrook is a town in Coos County, New Hampshire, United States. The population was 2,301 at the 2010 census. Situated in the Great North Woods Region, it is bounded on the west by the Connecticut River and home to Beaver Brook Falls Natural Area; the main village of the town, where 1,394 people resided at the 2010 census, is defined as the Colebrook census-designated place, is located at the junction of U. S. Route 3 with New Hampshire Route 26; the town includes the villages of Kidderville, Upper Kidderville, Factory Village. Colebrook is part of NH − VT Micropolitan Statistical Area. First granted in 1762 by New Hampshire's Colonial Governor Benning Wentworth, the territory was named "Dryden", after English poet and playwright John Dryden. Due to the inability of its original grantees to settle the remote area, however, it was regranted in 1770 by Colonial Governor John Wentworth, who renamed it "Colebrook Town" after Sir George Colebrooke, the East India Company's chairman of the board, it was settled that same year by a single family by the name of Rosebrook, but the family was driven out by the Revolutionary War, further settlement did not occur until after the war's end.
The 1790 census recorded a population of 29, the town was incorporated as Colebrook on June 11, 1796. For many years, it was the shire town of the Northern Judicial District of Coos County. Today, it has a district branch of the Lancaster Superior Court. A conflicting account holds that the town "was called Coleburne and was granted to Sir George Colebrook and others, it was incorporated June 11, 1795."The first road through the town was known as River Road, taking a route, followed today by U. S. Route 3, the Daniel Webster Highway; the first surveyed lots in the town comprised about 100 acres each, running from River Road to the Connecticut River. Settlement proceeded up two new roads, Titus Hill Road and what is now Pleasant Street. Titus Hill leads southeast out of the town center up to high ground in the neighboring town of Columbia that supports farming, while Pleasant Street, now a short road in Colebrook village, led east up the valley of the Mohawk River to the area of East Colebrook, the present-day village of Kidderville, what was known as "Factory Village", which grew about 2 miles east of the present village of Colebrook around a woolen mill constructed in 1816.
In 1803, seven years after the incorporation of the town, historian Timothy Dwight wrote, "Everything in this township exhibits the activity and enterprise of its inhabitants. Their dwelling houses are principally of logs. Mills they have already." The first sawmill and gristmill in the town were constructed around 1800 by Andrew McAllaster and his son, William, on the west side of the Beaver Brook bridge on what is now Main Street at the north end of the present village. The first brick maker was the Loomis kiln, located north of the current village where the IGA grocery store now stands. A larger brickmaker, Pratt & Smith, constructed a large kiln about 1826 in the Factory Village area. In 1822 a new brick woolen mill was constructed in Factory Village along the Mohawk River and produced at its peak 6,000 to 7,000 pounds of finished wool per year, it was capable of producing 50 yards including flannel and blankets. What is now Colebrook village, located on the eastern edge of the Connecticut River bottomlands where the Mohawk River enters, began to grow in the decade following 1811, when the Walker House was constructed at the corner of present-day Main and Pleasant streets.
Commercial buildings began to appear in 1816 on the block of Main Street between Pleasant Street and Parsons Street. The area was noted for excellent farming soil. After the Coos Trail through Dixville Notch was created in 1803, farmers loaded sleds each winter with potash, pearlash and other produce, including potato whiskey, to exchange in Portland, for molasses and other necessities. According to the 1874 Gazetteer, Colebrook was the Potato Capital of New Hampshire, producing over 120,000 bushels per year, most of which were milled into potato starch; some were distilled into "potato whiskey." This industry dated back to 1848, when Sherburn R. Merrill bought land in Factory Village along the Mohawk River to build a starch mill with 150 tons capacity. Other starch factories soon followed. At its peak, the town was producing, according to James O. Adams in 1877, "approximately one third of the potato starch in the state. Considered another way, one twentieth of all the starch produced in the United States came from the Colebrook area during this period."
The starch industry began to decline after 1880, due to lack of fertilization in the area's potato farms. The area turned to dairy farming. Abundant regional forests helped Colebrook become a lumbering center, with the first sawmill established at Beaver Brook in 1800. Between 1868 and 1915, the town was witness to great log drives. Other local manufacturing businesses, including blacksmiths, bobbin mills, boot- and shoemakers, carriage shops and tanneries, grew in the area through the 1800s, until the arrival of the railroad in 1887 connected the town to larger suppliers of goods. Tourism has been a growing component of Colebrook's economy since the 19th century; as early as 1804, an inn was constructed by the McAllaster family on. Chamberlain's Tavern was was for a time the meeting place of the town's militia. Three large hotels were b
In 1954 Billboard magazine published three charts covering the best-performing country music songs in the United States: Most Played in Juke Boxes, National Best Sellers, Most Played By Jockeys. All three charts are considered part of the lineage of the current Hot Country Songs chart, first published in 1958; the number one position on all three charts was dominated in 1954 by singer Webb Pierce, who had inherited the mantle of the most popular act in country music since the death of Hank Williams in 1953 and, in the midst of a run of success which included ten chart-toppers in a four-year period. On the best sellers chart, Pierce's singles "There Stands the Glass", "Slowly" and "More and More" spent a combined total of 32 weeks in the top spot. On the juke box chart, the same three songs spent 29 weeks at number one, or 30 if the chart dated March 6 is counted twice, as in that week two of Pierce's songs tied for the top spot. On the jockeys chart, Pierce spent a total of 29 weeks at number one with four songs, including "Even Tho", which did not reach the top of the other two listings.
The longest-running number one song of the year on all three charts was Hank Snow's "I Don't Hurt Anymore". The Canadian singer spent twenty consecutive weeks atop the best sellers chart with the song, the only chart-topper of the year on that listing not to be by Pierce; the song spent twenty non-consecutive weeks at number one on the juke box chart, a total of eighteen weeks in the top spot on the jockeys listing. One act achieved a debut country number one in 1954. Johnnie & Jack spent two weeks in the top spot of the jockeys chart with " I Get So Lonely", the only number one for the duo. a. ^ Two songs tied for number one. 1954 in music 1954 in country music List of artists who reached number one on the U. S. country chart
Fannie Porter was a well-known madam in 19th-century Texas, in the United States. She was best known for her popular brothel. Porter was traveled to the United States around the age of one with her family. By age 15, she was working as a prostitute in Texas. By the age of 20, she had started her own brothel and became popular for having a cordial and sincere attitude, choosing only the most attractive young women as her "girls", her requiring that her "girls" practice good hygiene, for maintaining an immaculate personal appearance, her brothel was located at the corner of Durango and San Saba streets, better known as the Sporting District. By 1895, her brothel in San Antonio was one of the more popular of the Old West, it had become known as a frequent stop off for outlaws. Butch Cassidy, the Sundance Kid, Kid Curry, other members of the Wild Bunch gang frequented her business. Della Moore, one of her "girls", became the girlfriend to Kid Curry, remaining with him until her arrest for passing money from one of his robberies.
Lillie Davis, another of her "girls", became involved with outlaw and Wild Bunch member Will "News" Carver. She claimed she had married Carver in Fort Worth before his death in 1901, but there are no records to verify the alleged marriage, it is possible that the Sundance Kid and his girlfriend Etta Place, whose true identity and eventual disappearance from history has long been a mystery, first met while she worked for Porter, but this never has been confirmed. Wild Bunch gang member Laura Bullion is believed to have at times worked for Porter between 1898 and 1901. Porter was well respected for her discretion, always refusing to turn in a wanted outlaw to the authorities, she was known for being defensive of her "girls", insisting that any who mistreated them never return to her brothel. She employed anywhere from five to eight girls, all ranging in ages from 18 to 25, all of whom lived and worked inside her brothel, her business was popular with outlaws of the day as well as with lawmen, she made sure that any lawmen who entered received the best treatment.
William Pinkerton, of the Pinkerton National Detective Agency, once paid her a visit. By the early 20th century, the tide had begun to turn against active operating brothels. Porter had been arrested in 1888 and 1891 but it was the investigation into her affiliation with the Wild Bunch that led her to move her operations to her home in 1901, she retired and faded from history. It is not known. Most agree; some stories indicate that she married a man of wealth, some indicate she retired into seclusion, others indicate she returned to England. None of those are confirmed. Rumors indicated that she lived until 1940, when she was killed in a car accident in El Paso, Texas. However, this is not certain. "Fannie Porter - San Antonio's Famous Madam". Texas Legends. Legends of America. Selcer, Richard F. "Porter, Fannie". Handbook of Texas Online. Texas State Historical Association. Carman, Ruby. "Fannie Weld Porter". Brothel Owner. Find a Grave
Karim Mouzaoui is a French former footballer of Algerian descent who played as a forward. Mouzaoui began his professional career with Strasbourg, but only played two Ligue 1 matches for the club, was loaned out to Laval where he played in 29 Ligue 2 matches, he moved to Greece and played for Apollon Kalamarias in the Greek Beta Ethniki, before moving to Greek Alpha Ethniki side Panionios. While at Panionios, Mouzaoui was suspended for four months after failing a doping test in January 2003. Next, Mouzaoui spent two seasons with Cypriot side Apollon Limassol before returning to Greece where he would play for Apollon Kalamarias and Veria F. C. in the Greek Super League. In 2008, he joined Makedonikos F. C. of the Greek Third Division. Profile at Racing Stub