The Jonesboro Metropolitan Statistical Area, as defined by the United States Census Bureau, is an area consisting of two counties – Craighead and Poinsett – in northeast Arkansas, anchored by the city of Jonesboro. As of the 2010 census, the MSA had a population of 121,026. It is also part of the larger Jonesboro-Paragould Combined Statistical Area.

Jonesboro is a city located on Crowley's Ridge in the northeastern corner of the U.S. State of Arkansas. Jonesboro is one of two county seats of Craighead County. In 2022, the city had an estimated population of 79,876, making it the fifth-most populous city in Arkansas. In 2020, the Jonesboro metropolitan area had a population of 134,196, and the Jonesboro-Paragould Combined Statistical Area had a population of 179,932.