Jonestown is a neighborhood in the southeastern district of Baltimore. Its boundaries are the north side of Pratt Street, the west side of Central Avenue, the east side of Fallsway, and the south side of Orleans Street. The neighborhood lies north of the Little Italy, south of the Old Town, west of the Washington Hill, and east of the Downtown Baltimore neighborhoods. The southern terminus of the Jones Falls Expressway is located here.

Baltimore is the most populous city in the U.S. state of Maryland. With a population of 585,708 at the 2020 census, it is the 30th-most populous city in the United States. Baltimore was designated an independent city by the Constitution of Maryland in 1851, and is currently the most populous independent city in the nation. As of the 2020 census, the population of the Baltimore metropolitan area was 2,838,327, the 20th-largest metropolitan area in the country. When combined with the larger Washington metropolitan area, the Washington–Baltimore combined statistical area (CSA) has a 2020 U.S. census population of 9,973,383, the third-largest in the country.