Julius Echter von Mespelbrunn was Prince-Bishop of Würzburg from 1573. He was born in Mespelbrunn Castle, Spessart and died in Würzburg.

The Prince-Bishopric of Würzburg was an ecclesiastical principality of the Holy Roman Empire located in Lower Franconia, west of the Prince-Bishopric of Bamberg. Würzburg had been a diocese since 743. As established by the Concordat of 1448, bishops in Germany were chosen by the canons of the cathedral chapter and their election was later confirmed by the pope. Following a common practice in Germany, the prince-bishops of Würzburg were frequently elected to other ecclesiastical principalities as well. The last few prince-bishops resided at the Würzburg Residence, which is one of the grandest Baroque palaces in Europe.