K-14 is a 219.3-mile-long (352.9 km) north–south state highway which runs through the central part of the U.S. state of Kansas. K-14's southern terminus is at U.S. Highway 160 (US-160) and K-2 in the city of Harper, and the northern terminus is a continuation as Nebraska Highway 14 (N-14) at the Nebraska border by Superior, Nebraska. Along the way it intersects several major east–west highways in the larger cities it passes through, including US-54 and US-400 by Kingman; US-50, K-61 and K-96 by South Hutchinson; K-156 and K-140 by South Ellsworth; Interstate 70 (I-70) and US-40 north of Ellsworth; K-18 in Lincoln; US-24 and K-9 in Beloit; and US-36 east of Mankato. The northern and southern halves of the highway differ fairly significantly in terms of terrain and landscape. The southern half of K-14 travels over fairly flat terrain in the valley of the Arkansas River. Just north of the intersection with K-4 in southern Ellsworth County, K-14 passes into the Smoky Hills region, traveling over a series of broad, rolling hills, providing several scenic vistas of the surrounding countryside. The portion of the highway between Lincoln and Beloit is particularly hilly.

U.S. Route 160 (US-160) is a part of the U.S. Highway System that runs from US-89 near Tuba City, Arizona east to US-67 and Missouri Route 158 southwest of Poplar Bluff, Missouri. In the state of Kansas, US-160 is a main east–west highway that runs from the Colorado border east to the Missouri border.