U.S. Route 160 (US-160) is a part of the U.S. Highway System that runs from US-89 near Tuba City, Arizona east to US-67 and Missouri Route 158 southwest of Poplar Bluff, Missouri. In the state of Kansas, US-160 is a main east–west highway that runs from the Colorado border east to the Missouri border.

U.S. Route 59 (US-59) is a part of the U.S. Highway System that runs from the Mexico–US border in Laredo, Texas, as a continuation of Mexican Federal Highway 85D north to the Lancaster–Tolstoi Border Crossing on the Canada–US border, where it continues as Manitoba Highway 59. In the U.S. state of Kansas, US-59 is a main north–south highway that travels from Chetopa to Atchison.