U.S. Route 160 (US-160) is a part of the U.S. Highway System that runs from US-89 near Tuba City, Arizona east to US-67 and Missouri Route 158 southwest of Poplar Bluff, Missouri. In the state of Kansas, US-160 is a main east–west highway that runs from the Colorado border east to the Missouri border.

U.S. Route 56 is an east–west United States highway that runs for approximately 640 miles (1,030 km) in the Midwestern United States. US 56's western terminus is at Interstate 25 Business, US 412 and New Mexico State Road 21 in Springer, New Mexico and the highway's eastern terminus is at US 71 in Kansas City, Missouri. Much of it follows the Santa Fe Trail.