Kane is a borough in McKean County in the U.S. state of Pennsylvania, 94 miles (151 km) east by southeast of Erie. It was founded in 1864 by Civil War General Thomas L. Kane of the famous Bucktail Regiment at an elevated site 2210 feet above sea level. In the early part of the 20th century, Kane had large glass works, bottle works, lumber mills, and manufactures of brush handles, saws, cutlery, screen doors and windows. The population peaked in the 1920s but has since declined to 3,612 people in 2020.

McKean County is a rural county in the Commonwealth of Pennsylvania. As of the 2020 census, the population was 40,432. Its county seat is Smethport. The county was created in 1804 and organized in 1826. It was named in honor of former Pennsylvania Governor and Declaration of Independence signer Thomas McKean. The county is part of the North Central Pennsylvania region of the state.