The Karlovy Vary Region or Carlsbad Region is an administrative unit of the Czech Republic, located in the westernmost part of its historical region of Bohemia. It is named after its capital Karlovy Vary. Spas in the region include Karlovy Vary and Mariánské Lázně.

Karlovy Vary is a spa city in the Karlovy Vary Region of the Czech Republic. It has about 49,000 inhabitants. It lies at the confluence of the rivers Ohře and Teplá. It is named after Charles IV, Holy Roman Emperor and the King of Bohemia, who founded the city.