Karpathos, also Carpathos, is the second largest of the Greek Dodecanese islands, in the southeastern Aegean Sea. Together with the neighboring smaller Saria Island it forms the municipality of Karpathos, which is part of the regional unit Karpathos-Kasos. Because of its remote location, Karpathos has preserved many peculiarities of dress, customs and dialect, the last resembling those of Crete and Cyprus. The island has also been called Carpathus in Latin and Scarpanto in Italian.

The Dodecanese are a group of 15 larger and 150 smaller Greek islands in the southeastern Aegean Sea and Eastern Mediterranean, off the coast of Turkey's Anatolia, of which 26 are inhabited. This island group generally defines the eastern limit of the Sea of Crete. They belong to the wider Southern Sporades island group.