Karpathos Island National Airport is an airport on the island of Karpathos, Greece. The airport first operated in 1970,and it had very limited facilities. As of 2023, its buildings cover an area of 12,500 m2. The current airport facilities were constructed between 2005 and 2009. The inauguration of the new airport terminal took place on 25 July 2009.

Karpathos, also Carpathos, is the second largest of the Greek Dodecanese islands, in the southeastern Aegean Sea. Together with the neighboring smaller Saria Island it forms the municipality of Karpathos, which is part of the regional unit Karpathos-Kasos. Because of its remote location, Karpathos has preserved many peculiarities of dress, customs and dialect, the last resembling those of Crete and Cyprus. The island has also been called Carpathus in Latin and Scarpanto in Italian.