The Kelso Home for Girls, formerly the Kelso Home and Orphan Asylum in Baltimore, Maryland, was a 19th-century orphanage and school building for girls on East Baltimore Street in the Jonestown/Old Town neighborhood, east of the Jones Falls. It was founded by businessman and philanthropist Thomas Kelso, (1784–1878), a former member of the old Methodist Episcopal Church, and inaugurated in January 1874. Formerly the Towson Family YMCA, it is now the Y of Central Maryland Towson Family Center.

Thomas Kelso was an Irish-American philanthropist and businessman, who was born in Clones, a market town in the north of Ireland, August 28, 1784. He died on the morning of July 26, 1878 at his home of many years on East Baltimore Street in Baltimore, Maryland, at the age of 94.