Kentucky's 5th congressional district is a congressional district in the U.S. state of Kentucky. Located in the heart of Appalachia in Southeastern Kentucky, it represents much of the Eastern Kentucky Coalfield. The rural district is the second most impoverished district in the nation and, as of the 2010 U.S. census, has the highest percentage of White Americans in the nation. It contains the counties of Bell, Boyd, Breathitt, Clay, Elliot, Floyd, Harlan, Jackson, Johnson, Knott, Knox, Laurel, Lawrence, Lee, Lincoln, Leslie, Letcher, Magoffin, Martin, McCreary, Menifee, Morgan, Owsley, Perry, Pike, Pulaski, Rockcastle, Rowan, Wayne, Whitley, Wolfe, and parts of Bath, and Carter counties. Within the district are the economic leading cities of Ashland, Pikeville, Prestonsburg, Middlesboro, Hazard, Jackson, Morehead, London, and Somerset. It is the most rural district in the United States, with 76.49% of its population in rural areas. It has been represented by Republican Hal Rogers since 1981.

The Eastern Kentucky Coalfield is part of the Central Appalachian bituminous coalfield, including all or parts of 30 Kentucky counties and adjoining areas in Ohio, West Virginia, Virginia, and Tennessee. It covers an area from the Allegheny Mountains in the east across the Cumberland Plateau to the Pottsville Escarpment in the west. The region is known for its coal mining; most family farms in the region have disappeared since the introduction of surface mining in the 1940s and 1950s.