Kentucky Route 160, also known as KY 160, is a state highway in the U.S. state of Kentucky. It runs from the Virginia state line, where the roadway continues east to Appalachia, Virginia as State Route 160, north via Lynch, Benham, Clutts, Cumberland, Sand Hill, Gordon, Linefork, Kings Creek, Premium, and Hot Spot to Kentucky Route 15 at Van. KY 160 overlaps KY 15 through Isom to Cody, where it splits to run via Carr Creek, Brinkley, and Hindman, ending at Kentucky Route 1087 at Vest. Due to the mountainous terrain and numerous tight bends. KY 160 is signposted closed to tractor-trailers from Lynch to the Virginia state line.

State Route 160 is a primary state highway in the U.S. state of Virginia. Known as the Trail of the Lonesome Pine, the state highway runs 8.02 miles (12.91 km) from the Kentucky state line on top of Black Mountain, where the highway continues north as Kentucky Route 160, east to SR 68 in Appalachia. Due to the mountainous terrain and numerous tight bends, Virginia State Route 160 and its Kentucky State Route 160 counterpart are signposted closed to tractor-trailers between Lynch, KY and Appalachia, VA.