Keoni Ana, full name John Kalaipaihala Young II, was a politician in the Kingdom of Hawaii, serving as Kuhina Nui of the Hawaiian Islands and Minister of Interior.

Kuhina Nui was a powerful office in the Kingdom of Hawaiʻi from 1819 to 1864. It was usually held by a relative of the king and was the rough equivalent of the 19th-century European office of Prime Minister or sometimes Regent.