Kernersville is a town in Forsyth County, North Carolina, and the largest suburb of Winston-Salem. The population was 26,481 at the 2020 census, an increase from 23,123 in 2010. The town is located in
U.S. Route 421 is part of the United States Numbered Highway System that runs from Fort Fisher, North Carolina to Michigan City, Indiana. In the U.S. state of North Carolina, US 421 travels 328 miles
Southern terminus of US 421 near Fort Fisher State Recreation Area
I-40 BUS/US 421/NC 150 near Kernersville. I-40 Business has since been decommissioned.
US 421 South near the Red White and Blue Road (exit 276) in eastern Wilkes County
King Street (US 421), going through downtown Boone