The Kesagami River is a river in northern Cochrane District in Northeastern Ontario, Canada. It is part of the James Bay drainage basin, and is a left tributary of the Harricana River. The lower two-thirds of the river, from about Kesagami Lake and downstream for 112 kilometres (70 mi) to its mouth, are part of Kesagami Provincial Park.

James Bay is a large body of water located on the southern end of Hudson Bay in Canada. It borders the provinces of Quebec and Ontario, and is politically part of Nunavut. Its largest island is Akimiski Island.